Sodium tolmetin dihydrate

Name	tolmetin sodium dihydrate
Synonyms	TOLMELINSODIUM Tolmetin Sodium tolmetinsodiumdihydrate sodiumtolmetindihydrate tolmetin sodium dihydrate Sodium tolmetin dihydrate Tolmetinsodiumsaltdihydratecrystalline 1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
CAS	64490-92-2
EINECS	626-708-5
InChI	InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;
InChIKey	QQILXENAYPUNEA-UHFFFAOYSA-M

Molecular Formula	C15H14NO3.Na.2H2O
Molar Mass	315.3
Melting Point	155-157 (dec.)
Boling Point	483.2°C at 760 mmHg
Flash Point	246°C
Water Solubility	Soluble in water
Solubility	Methanol (Slightly), Water (Slightly)
Vapor Presure	3.79E-10mmHg at 25°C
Appearance	Solid
Color	White to Beige
Storage Condition	-20°C Freezer
In vitro study	Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat. Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner. Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.
In vivo study	Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg. Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R38 - Irritating to the skin
Safety Description	36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	UX9280000
HS Code	2933995500

Last Update：2024-01-02 23:10:35

Product Name: Tolmetin Sodium Salt Dihydrate Visit Supplier Webpage Request for quotation
CAS: 64490-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Sodium tolmetin dihydrate Request for quotation
CAS: 64490-92-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380

Wechat: 15387090420

Product Name: Sodium tolmetin dihydrate Request for quotation
CAS: 64490-92-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

Wechat: 13605431940
WhatsApp: 13605431940